CXXC4

Across TCGA patient cohorts, CXXC4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXXC4-associated genes across cancer lineages are Ku80, p62 Lck ligand, and PDK1_pS241. Each is linked with CXXC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXXC4-to-partner and partner-to-CXXC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CXXC4-low versus CXXC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC4→partner) and Y-score (partner→CXXC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.399	+3.335	.001	.005	3	1
UCEC	p62 Lck ligand →	+0.386	+3.321	.023	.010	3	1
UCEC	PDK1_pS241 →	+0.194	+2.183	.030	.035	3	1
UCEC	4E-BP1_pS65 →	-0.242	-3.308	.018	.010	2	1
UCEC	RBM15 →	+0.382	+2.183	.022	.035	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Ku80 by CXXC4 expression — UCEC

Explore this box plot interactively →