CXCR6

Across TCGA patient cohorts, CXCR6 protein abundance is significantly associated with the RNA expression of many other genes, with 1,246 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CXCR6-associated genes across cancer lineages are SLA2, PPP1R16B, and PIM2. Each is linked with CXCR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR6-to-partner and partner-to-CXCR6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CXCR6 versus SLA2 in LSCC, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR6→partner) and Y-score (partner→CXCR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLA2 →	+0.956	+1.225	.002	.001	3	2
LSCC	PPP1R16B →	+1.069	+1.278	.001	<.001	3	2
LSCC	PIM2 →	+1.043	+1.275	.001	<.001	3	2
LSCC	MAP4K1 →	+1.112	+1.856	.004	<.001	3	2
LSCC	IL10RA →	+0.904	+1.278	.007	<.001	3	2
LSCC	POU2AF1 →	+1.370	+1.753	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,246 associations by consensus.

CXCR6 vs SLA2 — LSCC

Explore this scatter interactively →