CXCR6

Across TCGA patient cohorts, CXCR6 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR6-associated genes across cancer lineages are SF2, 14-3-3_beta, and A-Raf_pS299. Each is linked with CXCR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR6-to-partner and partner-to-CXCR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by CXCR6-low versus CXCR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR6→partner) and Y-score (partner→CXCR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.131	-1.752	.001	.014	3	2
UCEC	14-3-3_beta →	-0.106	-2.558	.004	.010	3	1
UCEC	A-Raf_pS299 →	-0.167	-1.906	<.001	.015	3	1
UCEC	ERK2 →	+0.218	+2.700	.002	.006	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.348	+1.415	.030	.046	3	1
UCEC	MEK1 →	+0.646	+3.321	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

SF2 by CXCR6 expression — UCEC

Explore this box plot interactively →