CXCR2P1

Across TCGA patient cohorts, CXCR2P1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR2P1-associated genes across cancer lineages are ER-alpha_pS118, EGFR_pY1173, and ERK2. Each is linked with CXCR2P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR2P1-to-partner and partner-to-CXCR2P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by CXCR2P1-low versus CXCR2P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR2P1→partner) and Y-score (partner→CXCR2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	+0.400	+3.013	.016	.018	3	2
UCEC	EGFR_pY1173 →	+0.085	+2.611	.023	.006	3	1
UCEC	ERK2 →	+0.177	+3.000	.048	.036	3	1
UCEC	GSK3-a-b →	-0.131	-3.000	.038	.036	3	1
UCEC	MEK1 →	+0.381	+3.000	.025	.036	3	1
UCEC	Rab11 →	-0.161	-2.584	.017	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ER-alpha_pS118 by CXCR2P1 expression — UCEC

Explore this box plot interactively →