CXCR1

Across TCGA patient cohorts, CXCR1 mutation is significantly associated with the RNA expression of many other genes, with 599 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR1-associated genes across cancer lineages are MIR33A, GUSBP8, and MIR557. Each is linked with CXCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCR1-to-partner and partner-to-CXCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR33A grouped by CXCR1-low versus CXCR1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR1→partner) and Y-score (partner→CXCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR33A →	+0.607	+4.693	<.001	.007	3	2
COAD	GUSBP8 →	+0.628	+4.510	<.001	.005	3	2
BRCA	MIR557 →	+0.240	+5.711	.001	.001	3	2
BRCA	LINC01941 →	+0.158	+4.575	<.001	.009	3	2
SKCM	C1QTNF3 →	-1.484	-3.662	.001	.001	3	2
SKCM	PNMA8B →	-0.267	-2.649	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 599 associations by consensus.

MIR33A by CXCR1 expression — COAD

Explore this box plot interactively →