CXCR1

Across TCGA patient cohorts, CXCR1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCR1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, STAT3_pY705, and EGFR_pY1068. Each is linked with CXCR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXCR1-to-partner and partner-to-CXCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CXCR1-low versus CXCR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCR1→partner) and Y-score (partner→CXCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.451	-3.321	.026	.010	3	3
UCEC	STAT3_pY705 →	-0.479	-3.584	<.001	.002	3	3
UCEC	EGFR_pY1068 →	-0.258	-2.459	.022	.019	3	2
UCEC	p90 RSK →	+0.193	+3.179	.025	.010	3	2
SKCM	ERK2 →	+0.201	+2.476	.006	.009	3	2
SKCM	p27_pT157 →	+0.130	+2.192	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p38-MAPK_pT180_Y182 by CXCR1 expression — UCEC

Explore this box plot interactively →