CXCL9

Across TCGA pan-cancer cohorts, CXCL9 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CXCL9 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CXCL9 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CXCL9 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where CXCL9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.977	0.164	.024	3	view →
HNSC	DFS	Quartile	II,III,IV	0.248	0.730	.033	2	view →
LSCC	DFS	Quartile	III,IV	0.475	1.000	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CXCL9–LUAD (OS)

Open the LUAD breakdown →