CXCL9

Across TCGA cell cohorts, CXCL9 RNA expression is significantly associated with the go_rna of many other GO terms, with 745 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CXCL9-associated GO terms across cancer lineages are Positive regulation of cellular extravasation, Positive regulation of type I interferon production, and Negative regulation of immune response. Each is linked with CXCL9 in more than 4 cancer types. Because this analysis shows association rather than direction, both CXCL9-to-partner and partner-to-CXCL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cellular extravasation grouped by CXCL9-low versus CXCL9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL9→partner) and Y-score (partner→CXCL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cellular extravasation →	+0.174	+0.014	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	Positive regulation of type I interferon production →	+0.055	+0.096	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of immune response →	+0.051	+0.070	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.124	+0.119	<.001	<.001	2	5
BREAST	Cellular response to starvation →	+0.034	+0.044	.002	.009	3	3
LARGE_INTESTINE	Non-motile cilium assembly →	-0.038	-0.066	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 745 associations by consensus.

Positive regulation of cellular extravasation by CXCL9 expression — BONE

Explore this box plot interactively →