CXCL3

Across TCGA patient cohorts, CXCL3 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL3-associated genes across cancer lineages are SSTR5, RNA5SP414, and RNA5SP412. Each is linked with CXCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL3-to-partner and partner-to-CXCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSTR5 grouped by CXCL3-low versus CXCL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL3→partner) and Y-score (partner→CXCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SSTR5 →	+1.240	+3.871	<.001	.002	3	1
UCEC	RNA5SP414 →	+1.031	+3.670	<.001	.002	3	1
UCEC	RNA5SP412 →	+1.329	+3.382	<.001	.004	3	1
UCEC	HNRNPCL3 →	+0.071	+3.608	<.001	.002	3	1
HNSC	WBP1LP3 →	+0.144	+7.954	<.001	.008	3	1
UCEC	MIR4672 →	+1.039	+5.211	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

SSTR5 by CXCL3 expression — UCEC

Explore this box plot interactively →