CXCL2

Across TCGA patient cohorts, CXCL2 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL2-associated genes across cancer lineages are RNU6-271P, MIR3170, and RNA5SP45. Each is linked with CXCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL2-to-partner and partner-to-CXCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-271P grouped by CXCL2-low versus CXCL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL2→partner) and Y-score (partner→CXCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-271P →	+0.574	+4.437	<.001	.001	3	2
UCEC	MIR3170 →	+0.853	+3.156	<.001	.006	3	1
BLCA	RNA5SP45 →	+0.303	+7.640	<.001	.009	3	1
UCEC	RPL23AP90 →	+0.460	+3.539	.003	.007	3	1
UCEC	MIR98 →	+0.509	+3.386	<.001	.008	3	1
UCEC	MIR7845 →	+0.757	+3.253	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RNU6-271P by CXCL2 expression — UCEC

Explore this box plot interactively →