CXCL16

Across TCGA patient cohorts, CXCL16 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL16-associated genes across cancer lineages are MEK1, Shc_pY317, and Caspase-8. Each is linked with CXCL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL16-to-partner and partner-to-CXCL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CXCL16-low versus CXCL16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL16→partner) and Y-score (partner→CXCL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.522	+2.999	.006	.035	3	2
UCEC	Shc_pY317 →	-0.190	-3.321	.016	.010	3	1
UCEC	Caspase-8 →	-0.274	-2.973	.037	.035	3	1
UCEC	ERK2 →	+0.289	+3.321	.004	.010	2	1
UCEC	TIGAR →	+0.203	+2.196	.011	.034	2	1
UCEC	TFRC →	+0.625	+3.321	.024	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by CXCL16 expression — UCEC

Explore this box plot interactively →