CXCL16

Across TCGA cell cohorts, CXCL16 mutation is significantly associated with the mutation status of many other genes, with 801 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CXCL16-associated genes across cancer lineages are CDC23, SRPK1, and POMT2. Each is linked with CXCL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL16-to-partner and partner-to-CXCL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC23 grouped by CXCL16-low versus CXCL16-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL16→partner) and Y-score (partner→CXCL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDC23 →	+5.672	+5.672	<.001	<.001	1	1
LARGE_INTESTINE	SRPK1 →	+3.087	+4.392	.005	.005	1	1
LARGE_INTESTINE	POMT2 →	+3.672	+4.799	.002	.002	1	1
LARGE_INTESTINE	OCEL1 →	+4.087	+5.044	.001	.001	1	1
LARGE_INTESTINE	HNRNPM →	+3.087	+4.392	.005	.005	1	1
LARGE_INTESTINE	HCN2 →	+3.350	+4.584	.003	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 801 associations by consensus.

CDC23 by CXCL16 expression — LARGE_INTESTINE

Explore this box plot interactively →