CXCL12

Across TCGA pan-cancer cohorts, CXCL12 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CXCL12 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CXCL12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CXCL12 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, UCEC, and HNSC are the cancer types where CXCL12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.919	1.000	.013	78	view →
UCEC	OS	Median	II,III,IV	0.522	1.000	.003	24	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	8	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	7	view →
LSCC	DFS	Tertile	II,III,IV	0.887	0.214	.017	5	view →
PDAC	DFS	Median	IV	0.245	0.934	.038	3	view →
GBM	OS	Quartile	All	0.758	0.995	.008	2	view →
LUAD	DFS	Tertile	II,III,IV	0.645	0.908	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CXCL12–COAD (DFS)

Open the COAD breakdown →