CXCL12

Across TCGA patient cohorts, CXCL12 protein abundance is significantly associated with the RNA expression of many other genes, with 14,018 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CXCL12-associated genes across cancer lineages are SRPX, MEOX2, and F13A1. Each is linked with CXCL12 in more than 7 cancer types. Because this analysis shows association rather than direction, both CXCL12-to-partner and partner-to-CXCL12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CXCL12 versus SRPX in BRCA, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL12→partner) and Y-score (partner→CXCL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX →	+1.139	+0.817	<.001	<.001	3	8
UCEC	MEOX2 →	+1.120	+1.050	<.001	<.001	3	7
GBM	F13A1 →	+1.703	+0.568	<.001	<.001	3	7
UCEC	CDO1 →	+1.254	+0.923	<.001	<.001	3	7
UCEC	FGF7 →	+1.191	+0.874	<.001	<.001	3	7
BRCA	COLEC12 →	+1.372	+0.847	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,018 associations by consensus.

CXCL12 vs SRPX — BRCA

Explore this scatter interactively →