CXCL12

Across TCGA patient cohorts, CXCL12 mutation is significantly associated with the RNA expression of many other genes, with 2,684 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL12-associated genes across cancer lineages are PFAS, PER1, and PCBP1-AS1. Each is linked with CXCL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL12-to-partner and partner-to-CXCL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFAS grouped by CXCL12-low versus CXCL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL12→partner) and Y-score (partner→CXCL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PFAS →	+0.407	+1.914	.004	.009	3	2
UCEC	PER1 →	+0.587	+1.868	<.001	<.001	3	2
SKCM	PCBP1-AS1 →	+0.561	+2.623	<.001	.005	3	2
UCEC	PITPNB →	+0.415	+2.147	<.001	<.001	3	2
UCEC	GINS3 →	+0.351	+1.606	.005	.003	3	2
UCEC	NGRN →	+0.529	+3.108	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,684 associations by consensus.

PFAS by CXCL12 expression — UCEC

Explore this box plot interactively →