CXCL12

Across TCGA patient cohorts, CXCL12 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL12-associated genes across cancer lineages are mTOR_pS2448, PDCD4, and 14-3-3_beta. Each is linked with CXCL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL12-to-partner and partner-to-CXCL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CXCL12-low versus CXCL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL12→partner) and Y-score (partner→CXCL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.107	-1.514	.035	.015	3	2
UCEC	PDCD4 →	-0.595	-2.077	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.075	-2.295	.027	.033	3	1
UCEC	EGFR_pY1068 →	-0.199	-2.169	.019	.003	3	1
UCEC	ERK2 →	+0.201	+2.906	.002	.001	3	1
UCEC	FoxM1 →	+0.188	+1.594	.033	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

mTOR_pS2448 by CXCL12 expression — UCEC

Explore this box plot interactively →