CXCL12

Across TCGA cell cohorts, CXCL12 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,492 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CXCL12-associated GO terms across cancer lineages are Positive regulation of dopamine secretion, Negative regulation of leukocyte tethering or rolling, and Amyloid-beta clearance by transcytosis. Each is linked with CXCL12 in more than 8 cancer types. Because this analysis shows association rather than direction, both CXCL12-to-partner and partner-to-CXCL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of dopamine secretion grouped by CXCL12-low versus CXCL12-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL12→partner) and Y-score (partner→CXCL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of dopamine secretion →	+1.694	+3.935	<.001	<.001	3	9
SOFT_TISSUE	Negative regulation of leukocyte tethering or rolling →	+1.881	+4.238	<.001	<.001	3	7
SOFT_TISSUE	Amyloid-beta clearance by transcytosis →	+0.140	+3.549	<.001	<.001	3	6
SKIN	SRP-dependent cotranslational protein targeting to membrane →	+0.110	+1.267	<.001	<.001	3	6
SOFT_TISSUE	Protein targeting to vacuole involved in autophagy →	+0.193	+3.902	<.001	<.001	3	6
OVARY	Response to acid chemical →	+0.064	+0.944	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,492 associations by consensus.

Positive regulation of dopamine secretion by CXCL12 expression — LIVER

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