CXCL11

Across TCGA patient cohorts, CXCL11 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL11-associated genes across cancer lineages are GSK-3a-b_pS21_S9, STAT3_pY705, and Tuberin_pT1462. Each is linked with CXCL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL11-to-partner and partner-to-CXCL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by CXCL11-low versus CXCL11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL11→partner) and Y-score (partner→CXCL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.488	+2.817	.037	.036	3	1
UCEC	STAT3_pY705 →	-0.372	-3.169	.009	.020	3	1
UCEC	Tuberin_pT1462 →	+0.306	+3.009	.015	.019	3	1
UCEC	ATM →	-0.804	-3.169	.001	.020	3	1
UCEC	Gab2 →	+0.389	+3.169	.047	.020	1	1
UCEC	p27_pT198 →	+0.158	+3.169	.007	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GSK-3a-b_pS21_S9 by CXCL11 expression — UCEC

Explore this box plot interactively →