CXCL11

Across TCGA cell cohorts, CXCL11 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,208 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CXCL11-associated GO terms across cancer lineages are Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity, Cellular response to exogenous dsRNA, and Cellular response to dsRNA. Each is linked with CXCL11 in more than 9 cancer types. Because this analysis shows association rather than direction, both CXCL11-to-partner and partner-to-CXCL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity grouped by CXCL11-low versus CXCL11-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL11→partner) and Y-score (partner→CXCL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity →	+0.105	+1.362	<.001	.007	3	10
OVARY	Cellular response to exogenous dsRNA →	+0.174	+0.505	<.001	.001	3	10
CNS	Cellular response to dsRNA →	+0.146	+1.056	<.001	<.001	3	10
PANCREAS	Activation of innate immune response →	+0.069	+0.905	<.001	<.001	3	9
BREAST	Regulation of positive chemotaxis →	+0.205	+0.945	<.001	.001	3	8
BREAST	Type I interferon-mediated signaling pathway →	+0.134	+0.645	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,208 associations by consensus.

Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity by CXCL11 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →