CXCL1

Across TCGA patient cohorts, CXCL1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXCL1-associated genes across cancer lineages are VHL, mTOR_pS2448, and C-Raf_pS338. Each is linked with CXCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXCL1-to-partner and partner-to-CXCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CXCL1-low versus CXCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL1→partner) and Y-score (partner→CXCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.778	-3.000	.047	.037	3	1
UCEC	mTOR_pS2448 →	-0.213	-3.000	.013	.037	2	1
UCEC	C-Raf_pS338 →	-0.100	-3.000	.034	.037	2	1
UCEC	53BP1 →	+0.540	+3.000	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

VHL by CXCL1 expression — UCEC

Explore this box plot interactively →