CXCL1

Across TCGA cell cohorts, CXCL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,369 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CXCL1-associated GO terms across cancer lineages are Negative regulation of cell adhesion molecule production, Regulation of cell adhesion molecule production, and Chemotaxis. Each is linked with CXCL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both CXCL1-to-partner and partner-to-CXCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell adhesion molecule production grouped by CXCL1-low versus CXCL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL1→partner) and Y-score (partner→CXCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of cell adhesion molecule production →	+1.465	+5.268	<.001	<.001	3	13
KIDNEY	Regulation of cell adhesion molecule production →	+1.431	+4.448	<.001	.003	3	12
KIDNEY	Chemotaxis →	+0.098	+4.611	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Cellular response to tumor necrosis factor →	+0.108	+3.577	<.001	.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of neutrophil chemotaxis →	+0.202	+3.449	.001	.006	3	9
KIDNEY	Taxis →	+0.098	+4.611	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,369 associations by consensus.

Negative regulation of cell adhesion molecule production by CXCL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →