CX3CR1

Across TCGA patient cohorts, CX3CR1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CX3CR1-associated genes across cancer lineages are Shc_pY317, XBP1, and Ku80. Each is linked with CX3CR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CX3CR1-to-partner and partner-to-CX3CR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CX3CR1-low versus CX3CR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CX3CR1→partner) and Y-score (partner→CX3CR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Shc_pY317 →	-0.156	-1.304	.014	.028	3	2
SKCM	XBP1 →	-0.187	-1.906	.022	.013	3	2
UCEC	Ku80 →	+0.360	+3.335	.003	.005	3	2
SKCM	Cyclin-B1 →	+0.406	+2.427	.002	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.181	-3.000	.040	.036	3	1
UCEC	ATM →	-0.780	-3.000	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Shc_pY317 by CX3CR1 expression — SKCM

Explore this box plot interactively →