CX3CR1

Across TCGA cell cohorts, CX3CR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,566 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CX3CR1-associated GO terms across cancer lineages are Lysosomal lumen acidification, Membrane fusion, and Protein deglycosylation. Each is linked with CX3CR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CX3CR1-to-partner and partner-to-CX3CR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by CX3CR1-low versus CX3CR1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CX3CR1→partner) and Y-score (partner→CX3CR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Lysosomal lumen acidification →	+0.111	+0.309	<.001	.003	3	6
BLOOD_Leukemia	Membrane fusion →	+0.027	+0.859	.001	.006	3	6
CNS	Protein deglycosylation →	+0.055	+0.035	.001	.006	3	5
BLOOD_Leukemia	Organelle fusion →	+0.033	+1.072	<.001	<.001	3	5
BLOOD_Leukemia	Nuclear envelope organization →	+0.044	+1.060	.003	.005	3	5
BLOOD_Leukemia	SA node cell to atrial cardiac muscle cell communication →	-0.663	-0.939	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,566 associations by consensus.

Lysosomal lumen acidification by CX3CR1 expression — BREAST

Explore this box plot interactively →