CX3CL1

Across TCGA patient cohorts, CX3CL1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CX3CL1-associated genes across cancer lineages are GSK-3a-b_pS21_S9, HER3, and SETD2. Each is linked with CX3CL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CX3CL1-to-partner and partner-to-CX3CL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by CX3CL1-low versus CX3CL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CX3CL1→partner) and Y-score (partner→CX3CL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.413	+2.179	.038	.034	3	1
UCEC	HER3 →	-0.270	-2.990	.035	.036	3	1
UCEC	SETD2 →	-0.203	-2.584	.045	.011	3	1
UCEC	ASNS →	+0.599	+2.321	<.001	.033	3	1
UCEC	Chk2 →	-0.344	-2.584	.001	.011	2	1
UCEC	p62 Lck ligand →	+0.366	+2.584	.015	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GSK-3a-b_pS21_S9 by CX3CL1 expression — UCEC

Explore this box plot interactively →