CWH43

Across TCGA pan-cancer cohorts, CWH43 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CWH43 data layer compared with 17 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher CWH43 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CWH43 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

ESCA, LUAD, and PAAD are the cancer types where CWH43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.190	0.707	<.001	33	view →
LUAD	OS	Median	II,III,IV	0.053	0.751	<.001	30	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
BLCA	OS	Median	III,IV	0.069	0.582	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	OS	Median	All	0.414	0.716	.030	3	view →
LIHC	OS	Median	All	0.234	0.673	.044	3	view →
SKCM	OS	Median	II,III,IV	0.926	0.827	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CWH43–ESCA (OS)

Open the ESCA breakdown →