CWH43

Across TCGA patient cohorts, CWH43 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CWH43-associated genes across cancer lineages are MEK1, p70-S6K_pT389, and Rb_pS807_S811. Each is linked with CWH43 in more than 1 cancer types. Because this analysis shows association rather than direction, both CWH43-to-partner and partner-to-CWH43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CWH43-low versus CWH43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWH43→partner) and Y-score (partner→CWH43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.432	+3.807	<.001	<.001	3	2
UCEC	p70-S6K_pT389 →	-0.192	-2.115	.002	.016	3	2
UCEC	Rb_pS807_S811 →	+0.283	+2.222	.034	.010	3	2
UCEC	ASNS →	+0.358	+1.362	.002	.034	3	2
UCEC	CD31 →	-0.125	-1.990	.010	.009	3	2
UCEC	Chk2_pT68 →	-0.159	-2.077	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

MEK1 by CWH43 expression — UCEC

Explore this box plot interactively →