CWH43

Across TCGA cell cohorts, CWH43 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CWH43-associated genes across cancer lineages are GUCY2F, GRK7, and SGIP1. Each is linked with CWH43 in more than 1 cancer types. Because this analysis shows association rather than direction, both CWH43-to-partner and partner-to-CWH43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCY2F grouped by CWH43-low versus CWH43-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWH43→partner) and Y-score (partner→CWH43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GUCY2F →	+0.007	+3.425	.002	<.001	3	1
LARGE_INTESTINE	GRK7 →	+0.116	+3.374	<.001	.005	3	1
LARGE_INTESTINE	SGIP1 →	+0.556	+3.614	.002	.002	3	1
LARGE_INTESTINE	TNFSF18 →	+0.305	+3.648	<.001	.002	3	1
LARGE_INTESTINE	GCM2 →	+0.053	+2.657	.001	.007	3	1
LARGE_INTESTINE	GFRA4 →	+0.018	+3.345	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GUCY2F by CWH43 expression — LARGE_INTESTINE

Explore this box plot interactively →