CWC27

Across TCGA pan-cancer cohorts, CWC27 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CWC27 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher CWC27 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CWC27 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, LIHC, and UCEC are the cancer types where CWC27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	30	view →
LIHC	OS	Median	All	0.059	0.774	<.001	24	view →
UCEC	DFS	Median	II,III,IV	1.000	0.440	.017	22	view →
STAD	DFS	Median	All	0.118	0.657	<.001	18	view →
BLCA	OS	Median	All	0.153	0.687	.013	9	view →
SKCM	DFS	Median	II,III,IV	0.015	0.709	<.001	8	view →
COAD	DFS	Median	All	0.164	0.505	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CWC27–LUSC (DFS)

Open the LUSC breakdown →