CWC27

Across TCGA pan-cancer cohorts, CWC27 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CWC27 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CWC27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CWC27 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where CWC27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.663	1.000	.002	22	view →
HNSC	DFS	Median	All	0.698	1.000	.020	13	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
LSCC	DFS	Tertile	III,IV	0.671	1.000	.027	6	view →
UCEC	OS	Median	All	0.916	0.983	.041	2	view →
LUAD	OS	Quartile	II,III,IV	0.864	0.438	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CWC27–CCRCC (DFS)

Open the CCRCC breakdown →