CWC27

Across TCGA cell cohorts, CWC27 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,278 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CWC27-associated GO terms across cancer lineages are Negative regulation of metaphase/anaphase transition of cell cycle, Negative regulation of chromosome separation, and Positive regulation of rRNA processing. Each is linked with CWC27 in more than 14 cancer types. Because this analysis shows association rather than direction, both CWC27-to-partner and partner-to-CWC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of metaphase/anaphase transition of cell cycle grouped by CWC27-low versus CWC27-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CWC27→partner) and Y-score (partner→CWC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.102	+0.554	<.001	<.001	3	14
LIVER	Negative regulation of chromosome separation →	+0.102	+0.554	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of rRNA processing →	+0.133	+0.602	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome segregation →	+0.107	+0.639	.008	.003	2	15
UPPER_AERODIGESTIVE_TRACT	Centriole replication →	+0.109	+0.676	<.001	.006	3	14
UPPER_AERODIGESTIVE_TRACT	Centrosome duplication →	+0.112	+0.721	<.001	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,278 associations by consensus.

Negative regulation of metaphase/anaphase transition of cell cycle by CWC27 expression — LIVER

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