CWC25

Across TCGA patient cohorts, CWC25 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CWC25-associated genes across cancer lineages are mTOR_pS2448, PCNA, and SLC1A5. Each is linked with CWC25 in more than 1 cancer types. Because this analysis shows association rather than direction, both CWC25-to-partner and partner-to-CWC25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CWC25-low versus CWC25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWC25→partner) and Y-score (partner→CWC25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.203	-2.986	.006	.035	3	1
UCEC	PCNA →	+0.302	+2.321	.005	.035	3	1
UCEC	SLC1A5 →	-0.440	-2.999	.039	.034	3	1
UCEC	EGFR_pY1173 →	+0.100	+2.827	.012	.035	2	1
UCEC	MEK1 →	+0.414	+2.321	.024	.035	2	1
UCEC	C-Raf_pS338 →	-0.119	-2.321	.003	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

mTOR_pS2448 by CWC25 expression — UCEC

Explore this box plot interactively →