CWC22

Across TCGA pan-cancer cohorts, CWC22 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CWC22 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CWC22 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CWC22 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where CWC22 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.948	0.639	.013	18	view →
HNSC	DFS	Quartile	III,IV	0.657	0.914	.017	15	view →
PDAC	DFS	Quartile	III,IV	0.358	0.902	.011	6	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →
CCRCC	DFS	Median	All	0.731	0.872	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CWC22–LSCC (OS)

Open the LSCC breakdown →