CWC22

Across TCGA patient cohorts, CWC22 mutation is significantly associated with the RNA expression of many other genes, with 2,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CWC22-associated genes across cancer lineages are RNA5S9, RNU6-176P, and TBC1D3P1-DHX40P1. Each is linked with CWC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CWC22-to-partner and partner-to-CWC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5S9 grouped by CWC22-low versus CWC22-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWC22→partner) and Y-score (partner→CWC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5S9 →	+0.247	+5.149	<.001	.003	3	2
SKCM	RNU6-176P →	+0.437	+3.730	<.001	.008	3	2
SKCM	TBC1D3P1-DHX40P1 →	+0.014	+4.495	.002	.007	3	2
UCEC	BRI3BP →	+0.568	+2.654	<.001	<.001	3	2
COAD	DRG1 →	+0.399	+3.459	.001	.005	3	2
UCEC	PDCD1 →	+0.817	+1.970	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,435 associations by consensus.

RNA5S9 by CWC22 expression — LIHC

Explore this box plot interactively →