CWC22

Across TCGA patient cohorts, CWC22 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CWC22-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and ASNS. Each is linked with CWC22 in more than 2 cancer types. Because this analysis shows association rather than direction, both CWC22-to-partner and partner-to-CWC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CWC22-low versus CWC22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWC22→partner) and Y-score (partner→CWC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.187	+2.817	<.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.447	+3.467	<.001	.002	3	2
COAD	ASNS →	+0.553	+3.321	.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.256	-1.925	.004	.005	3	1
UCEC	FoxM1 →	+0.222	+1.584	.017	.019	3	1
UCEC	INPP4B →	-0.316	-2.222	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by CWC22 expression — UCEC

Explore this box plot interactively →