CWC22

Across TCGA cell cohorts, CWC22 mutation is significantly associated with the RNA expression of many other genes, with 523 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CWC22-associated genes across cancer lineages are INTS10, TGFBI, and PCK1. Each is linked with CWC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CWC22-to-partner and partner-to-CWC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INTS10 grouped by CWC22-low versus CWC22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWC22→partner) and Y-score (partner→CWC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	INTS10 →	+0.543	+3.169	.008	.009	3	2
LARGE_INTESTINE	TGFBI →	-2.080	-2.541	.007	.005	3	2
LARGE_INTESTINE	PCK1 →	+1.675	+3.321	<.001	.003	3	2
LARGE_INTESTINE	ENTPD1 →	+0.556	+3.389	<.001	.001	3	2
LARGE_INTESTINE	TRMT10A →	+0.588	+3.082	.002	.007	3	2
LARGE_INTESTINE	C9orf72 →	+0.699	+2.628	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 523 associations by consensus.

INTS10 by CWC22 expression — LARGE_INTESTINE

Explore this box plot interactively →