CWC15

Across TCGA pan-cancer cohorts, CWC15 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CWC15 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CWC15 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CWC15 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where CWC15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.226	1.000	<.001	63	view →
LSCC	OS	Median	II,III,IV	0.916	0.646	.002	15	view →
GBM	OS	Quartile	All	0.598	0.320	.004	10	view →
PDAC	DFS	Quartile	All	0.829	0.675	.014	8	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	7	view →
LUAD	OS	Median	III,IV	0.625	0.226	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CWC15–HNSC (OS)

Open the HNSC breakdown →