CUZD1

Across TCGA patient cohorts, CUZD1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUZD1-associated genes across cancer lineages are Chk1, ATM, and Myosin-IIa_pS1943. Each is linked with CUZD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUZD1-to-partner and partner-to-CUZD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by CUZD1-low versus CUZD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUZD1→partner) and Y-score (partner→CUZD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.283	+2.472	<.001	.010	3	2
UCEC	ATM →	-0.716	-3.700	<.001	.001	3	2
UCEC	Myosin-IIa_pS1943 →	+0.229	+2.235	.009	.006	3	2
UCEC	Myosin-IIa →	+0.200	+3.180	.011	.010	3	2
UCEC	S6_pS240_S244 →	+0.412	+2.321	.016	.034	3	2
UCEC	Cyclin-B1 →	+0.777	+3.321	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Chk1 by CUZD1 expression — SKCM

Explore this box plot interactively →