CUX2

Across TCGA patient cohorts, CUX2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUX2-associated genes across cancer lineages are ATM, PDCD4, and TFRC. Each is linked with CUX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CUX2-to-partner and partner-to-CUX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CUX2-low versus CUX2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUX2→partner) and Y-score (partner→CUX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.566	-3.584	<.001	.002	3	4
UCEC	PDCD4 →	-0.430	-1.765	.002	.011	3	3
LUSC	TFRC →	+0.496	+3.584	.037	.002	3	3
UCEC	A-Raf_pS299 →	-0.097	-1.847	.007	.007	3	3
SKCM	STAT3_pY705 →	-0.183	-1.551	.018	.006	3	3
LUSC	B-Raf →	+0.292	+1.888	.041	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by CUX2 expression — COAD

Explore this box plot interactively →