CUX2

Across TCGA cell cohorts, CUX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,334 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CUX2-associated GO terms across cancer lineages are Positive regulation of DNA repair, Regulation of double-strand break repair, and Positive regulation of double-strand break repair. Each is linked with CUX2 in more than 9 cancer types. Because this analysis shows association rather than direction, both CUX2-to-partner and partner-to-CUX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by CUX2-low versus CUX2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CUX2→partner) and Y-score (partner→CUX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA repair →	+0.101	+2.999	<.001	<.001	3	10
BONE	Regulation of double-strand break repair →	+0.088	+1.919	<.001	.001	3	9
BONE	Positive regulation of double-strand break repair →	+0.104	+2.336	<.001	<.001	3	9
BONE	Positive regulation of DNA recombination →	+0.095	+1.844	<.001	<.001	3	9
BONE	Positive regulation of double-strand break repair via homologous recombination →	+0.076	+1.821	<.001	<.001	3	8
BONE	Epigenetic regulation of gene expression →	+0.107	+2.307	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,334 associations by consensus.

Positive regulation of DNA repair by CUX2 expression — BONE

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