CUX2

Across TCGA cell cohorts, CUX2 mutation is significantly associated with the RNA expression of many other genes, with 1,030 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUX2-associated genes across cancer lineages are LYG1, EYA3, and PDIK1L. Each is linked with CUX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CUX2-to-partner and partner-to-CUX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by CUX2-low versus CUX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUX2→partner) and Y-score (partner→CUX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.796	+2.222	<.001	.001	3	3
LARGE_INTESTINE	EYA3 →	+0.579	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	PDIK1L →	+0.458	+2.649	.006	.001	3	3
LARGE_INTESTINE	TXLNA →	+0.514	+3.404	.003	<.001	3	3
SKIN	STK32C →	+0.730	+2.043	<.001	.008	3	3
LARGE_INTESTINE	PICK1 →	+0.628	+1.721	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,030 associations by consensus.

LYG1 by CUX2 expression — LARGE_INTESTINE

Explore this box plot interactively →