CUX1

Across TCGA pan-cancer cohorts, CUX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CUX1 data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CUX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CUX1 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where CUX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.908	.033	30	view →
HNSC	OS	Tertile	All	1.000	0.941	.020	15	view →
PDAC	DFS	Quartile	III,IV	0.901	0.293	.008	11	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.651	.013	9	view →
LUAD	OS	Median	II,III,IV	1.000	0.862	.004	8	view →
CCRCC	OS	Tertile	III,IV	0.261	0.981	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CUX1–COAD (DFS)

Open the COAD breakdown →