CUX1

Across TCGA patient cohorts, CUX1 mutation is significantly associated with the RNA expression of many other genes, with 6,983 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUX1-associated genes across cancer lineages are KRTAP1-4, MIR4510, and TMEM33. Each is linked with CUX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CUX1-to-partner and partner-to-CUX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-4 grouped by CUX1-low versus CUX1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUX1→partner) and Y-score (partner→CUX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	KRTAP1-4 →	+0.215	+5.219	<.001	.006	3	4
SKCM	MIR4510 →	+0.080	+3.163	<.001	.003	3	4
UCEC	TMEM33 →	+0.452	+1.508	<.001	<.001	3	4
COAD	CACYBP →	+0.412	+3.183	.006	.009	3	4
UCEC	PDS5A →	+0.501	+2.327	<.001	<.001	3	4
COAD	IER3IP1 →	+0.673	+3.598	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,983 associations by consensus.

KRTAP1-4 by CUX1 expression — READ

Explore this box plot interactively →