CUX1

Across TCGA cell cohorts, CUX1 mutation is significantly associated with the RNA expression of many other genes, with 1,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUX1-associated genes across cancer lineages are XPC, CD1E, and NUCB2. Each is linked with CUX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUX1-to-partner and partner-to-CUX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XPC grouped by CUX1-low versus CUX1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUX1→partner) and Y-score (partner→CUX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	XPC →	+0.709	+2.944	.007	.007	3	2
BLOOD_Leukemia	CD1E →	+2.289	+2.775	.002	.005	3	2
BLOOD_Leukemia	NUCB2 →	+1.178	+3.199	.008	.007	3	2
LARGE_INTESTINE	DESI2 →	+0.446	+3.850	.003	<.001	3	2
LARGE_INTESTINE	TMEM50B →	+0.507	+2.743	.001	.001	3	2
LARGE_INTESTINE	TRMT10A →	+0.858	+2.667	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,590 associations by consensus.

XPC by CUX1 expression — STOMACH

Explore this box plot interactively →