CUX1

Across TCGA cell cohorts, CUX1 mutation is significantly associated with the mutation status of many other genes, with 6,570 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUX1-associated genes across cancer lineages are TULP4, DDX59, and SBF1. Each is linked with CUX1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CUX1-to-partner and partner-to-CUX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TULP4 grouped by CUX1-low versus CUX1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUX1→partner) and Y-score (partner→CUX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TULP4 →	+3.608	+3.906	.004	.004	1	7
OVARY	DDX59 →	+3.217	+3.684	.006	.006	1	6
SKIN	SBF1 →	+3.169	+4.548	.004	.004	1	6
LARGE_INTESTINE	B4GALNT3 →	+2.118	+2.118	.001	.001	1	6
BREAST	CIC →	+2.900	+3.557	.002	.002	1	5
LUNG_NSCLC_LUAD	PLXNA2 →	+2.893	+3.321	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,570 associations by consensus.

TULP4 by CUX1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →