CUTC

Across TCGA patient cohorts, CUTC mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUTC-associated genes across cancer lineages are MIG-6, ATM, and MEK1. Each is linked with CUTC in more than 1 cancer types. Because this analysis shows association rather than direction, both CUTC-to-partner and partner-to-CUTC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by CUTC-low versus CUTC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUTC→partner) and Y-score (partner→CUTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.089	+2.013	.047	.018	3	2
UCEC	ATM →	-0.679	-3.169	<.001	.019	3	2
UCEC	MEK1 →	+0.427	+2.000	.009	.032	3	1
UCEC	MYH11 →	+1.023	+2.000	.048	.032	3	1
UCEC	Notch1 →	+0.177	+3.183	.005	.009	3	1
UCEC	p27_pT198 →	+0.125	+2.000	.009	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MIG-6 by CUTC expression — UCEC

Explore this box plot interactively →