CUL7

Across TCGA pan-cancer cohorts, CUL7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CUL7 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CUL7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CUL7 expression acts as an unfavorable survival marker.

LUAD, HNSC, and CCRCC are the cancer types where CUL7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.654	0.902	.001	72	view →
HNSC	DFS	Median	All	0.303	0.886	.007	28	view →
CCRCC	DFS	Median	II,III,IV	0.445	0.825	.004	19	view →
UCEC	OS	Tertile	All	0.897	1.000	.017	10	view →
PDAC	DFS	Quartile	All	0.706	0.932	.010	8	view →
GBM	DFS	Median	All	0.669	0.822	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CUL7–LUAD (OS)

Open the LUAD breakdown →