CUL7

Across TCGA pan-cancer cohorts, CUL7 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CUL7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CUL7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CUL7 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

HNSC, LUAD, and CCRCC are the cancer types where CUL7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CUL7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.146	.003	7	view →
LUAD	All	II,III,IV	+0.145	<.001	6	view →
CCRCC	Male	II,III,IV	−0.117	.008	5	view →
PDAC	All	III,IV	−0.259	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CUL7–HNSC

Open the HNSC breakdown →