CUL7

Across TCGA cell cohorts, CUL7 mutation is significantly associated with the RNA expression of many other genes, with 392 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUL7-associated genes across cancer lineages are TMEM132E, CYP27C1, and PROP1. Each is linked with CUL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL7-to-partner and partner-to-CUL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM132E grouped by CUL7-low versus CUL7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL7→partner) and Y-score (partner→CUL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM132E →	+0.322	+3.242	<.001	.007	3	2
BLOOD_Leukemia	CYP27C1 →	+0.033	+3.450	.005	.004	3	2
CNS	PROP1 →	+0.029	+3.643	<.001	.007	3	2
BONE	SCYGR5 →	+0.165	+4.169	<.001	.008	3	1
BONE	OOSP3 →	+0.041	+4.000	<.001	.008	3	1
BONE	DNAAF6 →	+0.024	+4.000	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 392 associations by consensus.

TMEM132E by CUL7 expression — BLOOD_Leukemia

Explore this box plot interactively →