CUL5

Across TCGA pan-cancer cohorts, CUL5 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CUL5 data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CUL5 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated CUL5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, BRCA, and SKCM are the cancer types where CUL5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	1.000	0.346	.018	11	view →
BRCA	OS	Median	All	0.714	0.963	.018	10	view →
SKCM	DFS	Median	All	0.200	0.643	.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	OS	Median	III,IV	0.168	0.691	.041	6	view →
UCEC	DFS	Median	All	0.954	0.827	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CUL5–BLCA (OS)

Open the BLCA breakdown →