CUL5

Across TCGA pan-cancer cohorts, CUL5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CUL5 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CUL5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CUL5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where CUL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.865	0.667	.008	12	view →
CCRCC	DFS	Tertile	II,III,IV	0.864	0.270	.035	3	view →
GBM	OS	Quartile	All	0.229	0.605	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CUL5–PDAC (DFS)

Open the PDAC breakdown →